Is there Seronegative Rheumatoid arthritis?

Share This Post

Rheumatoid arthritis

It is possible to have seronegative rheumatoid-arthritis. Seronegative testing for rheumatoid arthritis means that the person is negative for both rheumatoid factors (RF) or cyclic citrullinated proges (CCP). This answer is complicated and requires some background. Rheumatoid arthritis is a condition that causes painful, swollen joints. It is different than osteoarthritis which causes joint damage due to aging.

When your immune system attacks your joints’ lining, you get RA. This is a complex phenomenon. RA can happen to anyone, but is most common in middle-aged women.

Popular Article:  why you need a family health guide

What is the best way to diagnose RA?

No single test can confirm that you have RA. The diagnosis includes a thorough examination of your joints, including blood tests and X-rays. Your doctor will likely refer you to a specialist, known as a rheumatologist, if they suspect you may have RA.

Factor Rheumatoid

The RF test, which can be used to confirm RA, is one of the blood tests. Your immune system makes RF, a protein (antibody), that binds to a normal antibody. This can lead to tissue inflammation. Elevated levels RF are common in autoimmune diseases such as RA or Sjogren’s Syndrome, and can also be caused by infections like parvovirus and hepatitis C.

Antibody CCP

However, RF testing does not provide a definitive diagnosis. Even though there are no autoimmune conditions, healthy people may have elevated blood RF levels with advanced age. People with RA may have normal levels of RF, which can further complicate matters. Some people may test positive for an antibody that is directed against cyclic citrullinated progesterones (CCP). Anti-CCP antibody (also known as CCP antibody) is more sensitive than RF and can be detected before RF.

Don’t Miss: dental veneers giving everyone the perfect smile


A person with RA symptoms but normal RF/anti–CCP levels might not have RA. Spondyloarthritis is another inflammatory autoimmune disorder. This is particularly true if your spine or sacroiliac joints are involved, or both.

Spondyloarthritis: The Disorders

Many of the conditions that fall under the umbrella of spondyloarthritis were thought to once be variants on RA. These include:

  • Psoriatic arthritis
  • reactive arthritis
  • Ankylosing Spondylitis
  • Enteropathic arthritis
  • Whipple’s Disease

Non-radiographic axial spine spondyloarthritis

Although each disorder is different, they all share the same root. All of them are inflammatory autoimmune diseases that can cause arthritis in different parts of the body, especially the spine.

Must Read: is ipl laser hair removal safe what are the risks

What is the difference between RA and spondyloarthritis?

Although these conditions may share arthritis, there are significant differences between RA (and the class of disease called spondyloarthritis). First, spondyloarthritis tends to be more common in men than in women.

Second, most spondyloarthritis cases include other complications, such as:

  • psoriasis
  • IBD (inflammatory bowel disease)
  • Inflammatory eye diseases
  • urethritis
  • Aphthous ulcer

The way arthritis is felt in RA and spondyloarthritis are different. Arthritis in RA can occur in the same joints on both the left and right sides of the body. Arthritis is not experienced in the same way in spondyloarthritis. It also affects tendons (tenosynovitis).

Inflammation is a common symptom of spondyloarthritis. It can often be found in the feet or ankles. Enthesitis can also occur in the spine, where the ligaments and tendons attach to the bones.

Recent Articles: looking at the many advantages of medjool dates

Treatments for spondyloarthritis

Unfortunately, spondyloarthritis, just like RA, has no cure. There are treatments that can help manage symptoms and prevent damage.

  • Nonsteroidal anti-inflammatory drug (NSAIDs),
  • Biologics and disease-modifying antirheumatic drug (DMARDs).
  • Topical creams to treat psoriasis
  • Eye inflammation can be treated with NSAID and steroid drops
  • Dietary changes to treat inflammatory bowel diseases (IBDs).
  • Janus-kinase inhibitors (JAK inhibitors)
  • Biologics

Related Articles

Tips and Tricks to Survive Your Next Medical Inspection

Tips and Tricks to Survive Your Next Medical Inspection Your first small business health inspection is likely to be in the food service sector. It...

Tips to Maintain Healthy Knees

Maintaining healthy knees requires taking several precautions. Elderly adults frequently experience knee issues. It may become difficult to walk, climb stairs, or get in and...

A Closer Look at Clinical Lab Technician Jobs in Vermont

If you’re looking for a career in healthcare, consider becoming a clinical lab technician. This job is currently in high demand in Vermont, with...

How to prepare for a health inspection

How should you prepare for an inspection? Be prepared for inspections at your restaurant by becoming more knowledgeable about the regulations and foodservice industry. Here...

What You Need to Know About Becoming a Physical Therapist

Physical therapists (PTs) are in high demand, with hospitals and clinics hiring them in large numbers at competitive salaries. If you're interested in breaking...

Simple Tips to Make Your Weekly Meal Prep Easier

Spend more quality time with your family by prepping meals, snacks and lunches ahead of time. Prepstart Lifestyle provides Meal Prep in Killeen TX...

What can I eat while taking Viagra?

Viagra works best when taken between 30 and 4 hours after administration, on an empty stomach. If you've recently eaten a large meal, skip...

Get the Winning Tactics For Cycling with this Indoor Cycling App

Cycling can be an exhilarating activity that everyone enjoys, yet few take the necessary effort to achieve success. If you want to improve your...

There are many types of public health degrees

There are many types of public health degrees that you can choose from Are you looking to make a positive impact in your career? Public...

Recent Articles

How to prepare for a health inspection

How should you prepare for an inspection? Be prepared for...


Your success is our goal at North Beach Health...

Tips to Relieve Pelvic Pregnancy Pain

Do you struggle with pelvic maternity discomfort? Do your butts,...

Tips to Make Sheet Pan Recipes More Delicious

The key to making meals that are easy to...

How to choose the best yoga mat

How to choose the best yoga mat THICKNESS Why it matters:...

What are the different criteria for getting the public health jobs?

Public health workers can do different types of jobs...


- Advertisement -spot_img
error: Content is protected !!